Tauroursodeoxycholic Acid-TUDCA is a water soluble bile acid. It shows great potency in treating cholestasis (bile acid backup in the liver) as the water soluble bile acids counteract the toxicity of regular bile acids. Can also protect and rehabilitate the liver, and general protects cells. Itís used as a therapy for people that have any type of issue with the liver or liver bile duct. You only have small amounts of this amazing compound in your body.
TUDCA helps protect these special cells that line heart and arteries. It reduces oxidative stress. It prevents the endothelial cells from becoming dysfunctional in the presence of too much glucose.
2. MILK THISTLE
The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin. Its herbal remedy is known as milk thistle extract. Milk thistle extract has a high amount of silymarin (between 65Ė80%) that has been concentrated from the milk thistle plant. Milk thistle is often promoted for its liver-protecting effects. Itís regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer. Itís also used to protect the liver against toxins like amatoxin, which is produced by the death cap mushroom and is deadly if ingested.
3. L-ORNITHINE L-ASPARTATE
L-ornithine-L-aspartate increases levels the ornithine and aspartic acid in the body. These amino acids help to reduce levels of a toxic chemical called ammonia in the blood. L-ornithine- L-aspartate (LOLA), the salt of the natural amino acids ornithine and aspartate acts through the mechanism of substrate activation to detoxify ammonia. In clinical trials, LOLA has shown a statistically significant effect with respect to reduction in HE (Hepatic encephalopathy) grade, reduction of blood ammonia concentration and positive effects on psychomotor function in patients of cirrhosis with minimal HE and overt chronic Grade I HE.
4. NAC (N-acetylcysteine)
Is a modified amino acid that is used to reverse the toxic effects of acetaminophen overdose and prevent acute liver failure. The amino acid cysteine has a thiol side chain that can undergo redox reactions and thus has antioxidant activity.Cysteine is required for synthesis of glutathione (a tripeptide of cysteine, glycine and glutamic acid) that is an essential intracellular antioxidant, providing protection against free radicals and other intracellular toxins including intermediates of drug metabolism. Glutathione can become depleted in patients with malnutrition, chronic debilitating illnesses and chronic alcoholism, and becomes acutely depleted in patients with acetaminophen overdose leading to formation of toxic adducts of acetaminophen metabolites with essential intracellular molecules. Restoration of glutathione stores ameliorates the cell injury from acetaminophen.Administration of acetylcysteine (also referred to as N-acetylcysteine or NAC) within 10 hours of an acetaminophen overdose effectively prevented serious liver injury. Subsequent studies suggested that administration even after 10 hours was partially effective and may also be beneficial in other, non-acetaminophen causes of acute liver failure, including drug induced liver injury.